Sunday, July 8, 2012

Nexus Q review: Google's mysterious little social streamer

DNP Nexus Q review Google's mysterious little social streamer

When setting up a gadget for review, delicately unboxing and smelling the carcinogenic whiff of freshly molded plastics, we typically feel some amount of excitement and anticipation to see how it stacks up against the competition. It's either that or a resigned sense of duty as we run yet another iterative evolution of this or that laptop through the same benchmarks to see just how this year's model stacks up to the older model now being sold on discount. With the Nexus Q, though, we felt something different altogether: genuine curiosity.

Why? Well, it's a high-end device with a $299 MSRP, a price that's multiple times higher higher than media streamers like the Apple TV, anything from Roku and, indeed, Google's own Google TV. And yet, the Q has considerably less functionality than any of them. Largely because of this, many who witnessed its unveiling at Google I/O were quick to write it off. Despite having our own doubts we pledged to give it a fair swing, a week of solid use at home and with friends. How did it do? Does this high-concept device with high-end componentry make up for some decidedly low-end capabilities? There's only one way to find out.

Continue reading Nexus Q review: Google's mysterious little social streamer

Nexus Q review: Google's mysterious little social streamer originally appeared on Engadget on Fri, 06 Jul 2012 12:30:00 EDT. Please see our terms for use of feeds.

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S.Africa: Tennis star investigated on rape claims

JOHANNESBURG (AP) ? Investigators on two continents are at last probing accusations a Hall of Fame tennis player was a serial pedophile, three decades after the alleged rapes.

But an advocate for child abuse victims in South Africa, one of the places where tennis star Bob Hewitt is accused of preying on young girls he coached, says the sporting world has yet to face the challenge of protecting children.

This week, the Newport, Rhode Island-based International Tennis Hall of Fame announced it had hired an attorney to investigate allegations that former doubles champion Hewitt sexually abused girls, an inquiry that could lead to his expulsion from the Hall. The Hall had earlier dismissed calls to expel Hewitt, who was inducted in 1992.

Also this week, South African police said they had completed an initial investigation into a rape case a South African woman filed against Hewitt in December. Police say they are awaiting guidance from prosecutors on how to proceed with a case involving allegations dating to the 1980s.

Hewitt, who lives in South Africa, has not commented on the allegations or investigations.

Luke Lamprecht, spokesman for the South African group Women and Men Against Child Abuse, said athletes, their parents and coaches must recognize that pedophiles seek opportunities in sports, just as they do in church, school and other organizations where children can be found.

Lamprecht said sports officials may shy away from acknowledging that because they think it reflects badly on them, but "they have a special responsibility in the same respect that the Catholic Church does.

"They absolutely do need to acknowledge that they are a haven."

Lamprecht said he has helped church and scouting groups write rules so that adults know what to do when a child says he or she has been abused. Squarely acknowledging the possibility makes it harder for pedophiles to hide, but Lamprecht said sporting authorities in South Africa lack such protocols.

"It empowers parents and children, to say, 'I know this happens, and this is what we do,'" Lamprecht said.

Officials from the South African Sports Confederation and Olympic Committee, which is the country's umbrella sports authority, and from the South African Tennis Association did not respond to requests for comment for this article.

The South African Tennis Association, like many sports authorities in the country, underwent a management change after apartheid ended in 1994. Terry Rosenberg, who helped oversee the transition for a brief period as president of the tennis association in the mid-1990s, said he was unaware of what information his predecessors had about Hewitt.

"Obviously if you're in charge and you had relevant information, you had to act on it," he said.

Lamprecht, who once managed Johannesburg's Teddy Bear Clinic, a center for sexually abused children, is familiar with the Hewitt case and has spoken to some of the accusers.

Lamprecht said a "coach predator" often starts by working to gain the trust of the parents.

"You have a person who can realize the dreams and aspirations of the child," Lamprecht said. "And those dreams and aspirations of the child are also often the dreams and aspirations of the parent."

In a memoir published last year, boxing champion Sugar Ray Leonard revealed publicly for the first time that he was sexually abused by a "prominent Olympic boxing coach" when he was a teenager.

Last year in Canada, former junior hockey coach Graham James pleaded guilty to sexually abusing former NHL star Theoren Fleury and another player. In a statement prepared for the court, Fleury said James "skillfully manipulated us all, and eventually my parents entrusted my care and well-being to him in order to allow me to move to other towns and cities to advance my hockey dream."

In the United States, former Penn State assistant football coach Jerry Sandusky was recently convicted of 45 criminal charges stemming from the abuse of 10 boys he met through a charity he established.

Suellen Sheehan, 43, the South African woman who filed the rape case against tennis star Hewitt in December, accuses Hewitt of raping her when she was 9.

She says allegations about Hewitt were the subject of speculation in the 1970s and 1980s. Sheehan said she told her mother at the time that Hewitt had abused her, but her mother "dismissed it."

Sheehan said it took her decades to overcome shame and guilt and go public with her allegations, which she and others first took to the Hall of Fame. When the Hall initially refused to expel Hewitt, she filed the police case.

Twiggy Tolken, a 44-year-old South African who now lives in New Zealand, said her family went to South African police with allegations against Hewitt when she was 13, but dropped the case because her parents did not want her to have to face Hewitt or his lawyer in court.

She said her father told South African tennis officials about the allegations, and then was shocked to see Hewitt being asked to escort young players on an international trip.

"They all knew, and not one of them did anything," Tolken said. "There was absolutely nothing done to stop this man."

The AP typically doesn't identify people who say they were sexually abused, unless they agree, as Sheehan and Tolken did, to be named publicly.

Ray Moore, South Africa's national coach at the time, said officials had no more than innuendo and suspicion.

Going after Hewitt, he said, would have been particularly difficult then because of his stature as an international star in a country that was isolated because of apartheid. Now, after hearing mounting accusations against Hewitt from women around the world, Moore is convinced Hewitt "has to be held accountable."

Moore is now based in the United States, where his company operates the BNP Paribas Open tennis tournament in Indian Wells, California. He said Americans are becoming increasingly aware of the dangers of pedophiles in the world of sports, and that he hoped the same was true for his homeland.

Sheehan and Tolken have spoken with the Hall of Fame's attorney and helped put him in touch with several others who say they were abused by Hewitt.

Source: http://news.yahoo.com/africa-tennis-star-investigated-rape-claims-211922115--spt.html

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Saturday, July 7, 2012

Pakistan's Texas-sized problems

Despite the some cultural overlaps, the American and Pakistani paths are parting ways.

By Scott Baldauf,?Staff writer / June 28, 2012

A Pashtun boy stands at the window of his family's mud house, looking at children playing nearby on the outskirts of Peshawar, Pakistan, last week.

Fayaz Aziz/Reuters

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Years ago, before Sept. 11, when I first started traveling in South Asia, a Pakistani diplomat gave me a quick tutorial about how his people, Pashtuns, were not so very different from my own people, Texans.

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We both follow conservative religions, although not so closely as we like others to believe, said the diplomat, delicately cutting into a plate of enchiladas at a Tex-Mex joint in Washington. Like Texans, we love our guns. We have very traditional beliefs about marriage and the role of women in society. We love barbecued meat. We distrust government, and hate paying taxes. We?re not as different as you might think.

As intriguing as this Pashtuns-are-Texans theory is, it is clear that the differences between the United States (which includes Texas, for the time being) and Pakistan (which includes many ethnic Pashtuns, for the time being) have become vast. US military airstrikes, aimed at Islamist militants but also killing civilians and even Pakistani soldiers, have turned many Pakistanis against what they see as a ?great Satan.? Pakistani tolerance of, and even support for, Islamist militant groups on Pakistani soil has pushed many US military commanders to conclude that Pakistan is, in effect, more an enemy than an ally. According to Christine Fair in this week?s Foreign Policy magazine, some are contemplating a new approach: either containment, or benign neglect.

At present, Pakistan no longer allows the US military or the NATO alliance to use its ports or roads to resupply NATO troops based in Afghanistan. And with US elections approaching, and Pakistan?s government increasingly fragile, it is hard to see how the two countries can bridge the gap.

Pakistani public opinion has turned sharply against the United States, with a recent Pew Research poll showing that 74 percent regard America to be an enemy, up from 69 percent in 2011, and 64 percent three years ago.

Recent headlines indicate that things are not getting better, but rather worse.

* In her?Foreign Policy piece, Ms. Fair suggests that US military are close to giving up on its tactical alliance with Pakistan. As Fair writes, Pakistan is in such a state of crisis, it couldn?t change course even if it wanted to do so.

Pakistan is in crisis. Its courts act on whim rather than jurisprudence. Its political parties are vast pools of corrupt patronage networks that aggregate elite interests while disregarding the interests of Pakistan's struggling masses. Neither elected politicians nor military rulers have had the political courage to right the nation's fiscal woes by enforcing income tax or imposing industrial and agricultural taxes on the ruling elites and their networks of influence. While the army has retrenched from a direct role in politics, it has done so likely because it has no other option: Pakistan's military suffered a mighty humiliation after the bin Laden raid, which left many citizens wondering whether their country is a failed state, a rogue state, or both.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/mc3y_ZT5GU8/Pakistan-s-Texas-sized-problems

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Video: Countdown to Jobs Report

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Eating Disorders: The Strive for Thinness | Diet-Fitness-Health ...

The truth about eating disorders and the strive for thinness. I made this video in honor of National Eating Disorder Awareness Week. This is a piece I wrote last May. I have been in recovery since August of 2010. :) Visit my blog: www.deniseasy-going.tumblr.com For more information about eating disorders, how to help raise awareness, and what resources are available, visit www.nationaleatingdisorders.org

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Source: http://myveryhealthy.com/todays-healthcare/eating-disorders-the-strive-for-thinness.html?utm_source=rss&utm_medium=rss&utm_campaign=eating-disorders-the-strive-for-thinness

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Friday, July 6, 2012

Cancer Therapeutics reveals proof of concept for second development drug

Cancer Therapeutics, a company focused on translating cancer biology research into novel treatments for cancer, today announced the validation and performance of a new targeted drug, CTx-294886, in combination with Avastin? (bevacizumab ? Genentech/Roche) in a preclinical model of breast cancer. At the same time the Company announced that it has developed a new High Throughput Screening (HTS) platform for the identification of small molecule inhibitors of protein ubiquitination, a key element in the essential cellular process of protein homeostasis, which is an exciting new target pathway for cancer treatment. Both scientific developments will be presented as posters at the EACR conference in Barcelona Spain on July 7-10 2012.

The anti-tumour response to CTx-0294886, a potent small molecule inhibitor of Focal Adhesion Kinase (FAK) and Vascular Endothelial Growth Factor Receptor 3 (VEGFR3), was compared with that of the Company?s first product CTx-0294945, a potent selective FAK inhibitor. CTx-0294886 in combination with Avastin?, showed additional benefits to those previously demonstrated by CTx-294945 (previously presented at the AACR conference in Chicago on the 3rd of April this year).? In both cases the small molecules in combination with Avastin? inhibited angiogenesis, and increased the duration of tumour response in a model of basal breast cancer.? In addition CTx-294886 in combination with Avastin? also provided a highly statistically significant increase in the median survival time compared to the Avastin? only group.

The new Ubiquitin HTS platform closely replicates cellular ubiquitination pathways, and provides a mechanism for HTS of multiple targets.? Ubiquitins are small regulatory proteins that attach to other target proteins allowing their destruction and recycling. This process requires a family of dedicated enzymes, such as ligases, for completion. E6AP, an E3 ligase, was selected to validate the platform.? E6AP ubiquitinates p53 and PML in human papilloma virus (HPV) related and other cancers. Both p53 and PML are well known suppressors of tumour growth so substances that inhibit E6AP would be expected to retard tumour growth in cancers such as cervical and head and neck cancers. The platform was able to identify several small molecules that are now undergoing further investigation.

Dr Warwick Tong, CEO of Cancer Therapeutics, commented:

?Having achieved preclinical validation for our first product candidate in conjunction with Avastin, we are delighted to be announcing that our second candidate is even more potent at prolonging and strengthening the effects of Avastin. We are excited to have two targeted molecules that will allow rational combinations with other therapies in the fight against cancer. We are now starting to reap the benefits of our highly collaborative approach to drug discovery, working hand in hand with some of the top research institutes in Australia and our international partner, Cancer Research Technology UK?.

Dr Ian Street, Chief Scientific Officer of Cancer Therapeutics, added:

?The launch of our new Ubiquitin HTS platform opens up the potential to collaborate with industry by screening chemical libraries to address multiple targets in this new and exciting area of cancer biology.? We are ready to begin discussions with other companies who would like to work with us to include their targets of interest and screen their chemical libraries using this platform?.

The titles of the posters being presented throughout the conference are:

Source: http://www.news-medical.net/news/20120704/Cancer-Therapeutics-reveals-proof-of-concept-for-second-development-drug.aspx

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Hometown Glory Bursary Contest Win a $5000 Bursary ...

Logo-150-by-60 What?s unique about your hometown? Capture the spirit of your hometown in a creative way for your chance at a bursary to Centre for Arts and Technology!

The task? To capture your hometown in a photo from a unique angle! Bird?s eye, panoramic, all-in-the-details, abstract, panning? how you want to capture your hometown is up to you-make it original!

Entries are due on July 31 and we will email you to give you the voting link so you can share your entry with friends and family (or your whole hometown!) to secure votes. Three rounds of voting will start on August 1, with a public vote determining voting round finalists, and ultimately, the top three entries during the final vote, from August 22nd to August 31. Winners will be announced on September 5, 2012!

The Centre for Arts and Technology, with campuses located in Kelowna BC, Halifax NS, and Fredericton NB, is an accredited, higher education institution. We provide specialized technical training and sought-after skills in a rapidly expanding and evolving entertainment arts and media production industry.

Our programs are led by and designed in conjunction with industry professionals. They include Digital Filmmaking Fusion, Digital Photography, Digital Filmmaking, Animation for Game, Film, & Visual Effects, Audio Engineering, Sound Production, Graphic Design & Web Development, Fashion Design, Interior Design, Network Security, and more.


Contest terms and conditions

Source: http://www.photographycompetitions.net/2012/07/hometown-glory-bursary-contest-win-a-5000-bursary/

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