Source: http://boards.footymad.net/forum.php?tno=551&fid=414&act=1&mid=2113317543
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Saturday, February 2, 2013
Golf & Zola's Lounge: re: How to turn your car into a shagmobile.
A positive family climate in adolescence is linked to marriage quality in adulthood
Jan. 31, 2013 ? Experiencing a positive family climate as a teenager may be connected to your relationships later in life, according to new research published in Psychological Science, a journal of the Association for Psychological Science.
While research has demonstrated long-term effects of aggression and divorce across generations, the impact of a positive family climate has received less attention. Psychological scientist Robert Ackerman of the University of Texas at Dallas and colleagues wanted to examine whether positive interpersonal behaviors in families might also have long-lasting associations with future relationships.
The researchers examined longitudinal data from individuals participating in the Iowa Youth and Families Project. Family interactions were assessed when the participants were in 7th grade. The interactions were coded for five indicators of positive engagement: listener responsiveness, assertiveness, prosocial behavior, effective communication, and warmth-support.
Participants who showed and experienced more positive engagement in their families showed more positive engagement in their marriages 17 years later. Interestingly, their spouses also showed more positive engagement. Participants who came from families that expressed more positive engagement also expressed less hostility toward their spouses, and their spouses displayed less hostile behavior toward them.
Greater levels of positive engagement at the family level in adolescence also predicted more relationship satisfaction for both partners.
At a basic level, the findings suggest a link between the family climate in adolescence and marriage quality later in life. The fact that these effects seemed to extend to participants' spouses was especially interesting.
"Perhaps one of the most striking results from this work was that the quality of one marital partner's family climate during adolescence was associated with marital outcomes for the other partner," the researchers observe.
Family dynamics could foster a supportive style of interacting that elicits similar behavior from a spouse down the road; but it could also be that individuals who grew up in families with a positive and warm climate actively seek out partners who provide a similar relationship environment. The researchers speculate that both mechanisms may be at work.
Ultimately, these results are consistent with the Development of Early Adult Romantic Relationships (DEARR) model, suggesting that early family experiences are linked to the development of a person's relationship style into adulthood.
Co-authors on the study include Deborah A. Kashy and M. Brent Donnellan of Michigan State University, Tricia Neppl and Fredrick O. Lorenz of Iowa State University, and Rand D. Conger of the University of California, Davis.
The analyses reported here were supported by Eunice Kennedy Shriver National Institute of Child Health and Human Development Grant HD064687.
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The above story is reprinted from materials provided by Association for Psychological Science.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- R. A. Ackerman, D. A. Kashy, M. B. Donnellan, T. Neppl, F. O. Lorenz, R. D. Conger. The Interpersonal Legacy of a Positive Family Climate in Adolescence. Psychological Science, 2013; DOI: 10.1177/0956797612447818
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/EXlw3ZKXKOw/130131120910.htm
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Friday, February 1, 2013
Programming cells: Importance of the envelope
Feb. 1, 2013 ? In a project that began with the retinal cells of nocturnal animals and has led to fundamental insights into the organization of genomic DNA, researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich show how the nuclear envelope affects nuclear architecture -- and gene regulation.
The double-stranded DNA molecules that make up the genetic material are wrapped around protein complexes to form compacted "chromatin." The active portion of the genome is less densely packed, and thus more easily accessible, than the inactive fraction, and is referred to as euchromatin. Euchromatin is typically located in the inner regions of the cell nucleus, while much of the inactive DNA in "heterochromatin" is associated with the inner face of the nuclear envelope. This type of chromatin organization is found in almost all higher organisms and may have been invented 500 million years ago.
But there is a curious exception to this generalization. In the retinal cells of nocturnal animals, the heterochromation is localized in the central area of the nucleus, as a research group led by LMU biologists Dr. Irina Solovei and Dr. Boris Joffe showed in a previous study. "This got us interested in the mechanisms that control the distribution of chromatin," says Professor Heinrich Leonhardt of LMU's Biozentrum. "How can the nuclear architecture in the rod cells of nocturnal animals be inverted in this way, and what determines the typical positioning of inactive chromatin on the outskirts of the nucleus in normal cells?" Leonhardt and his team have now completed an extensive study in search of the answers.
A fundamental principle unveiled
With the help of targeted genetic manipulations in the mouse, Joffe and Solovei together with their colleagues show for the first time that there are two independent mechanisms for fixing heterochromatin to the inner face of the nuclear envelope. These mechanisms make use of two different components of the inner nuclear membrane as clamps -- lamin A/C, and the so-called lamin-B receptor (LBR), which itself binds to B type lamins.
Normally the two components are used sequentially for this purpose. "In the course of differentiation, there is a switch from the LBR to lamin A/C, and there is always a least one type of tether available for attachment of heterochromatin to the nuclear periphery. But if both are missing, the inactive heterochromatin recoils like a severed elastic band and collapses in the center of the nucleus," explains Leonhardt. Moreover, the switch seems to be a fundamental principle of genome organization and cell differentiation in mammalian cells, as the researchers concluded from the study of 39 species and the analysis of diverse tissue types in nine genetic strains of mice.
Prospects for targeted therapies Lamin proteins not only have a structural function but also have an impact on gene regulation. Thus LBR binds B type lamins and regulates stem-cell populations by promoting the expression of genes that are important for the proliferation of rapidly dividing stem cells. The lamin A/C gene on the other hand codes for a structural component of the nuclear envelope, and regulates cellular differentiation programs like e.g. the expression of muscle-specific genes in muscle cells. Mutations in this gene result in so-called laminopathies -- rare genetic diseases that are associated with a broad spectrum of clinical symptoms, including muscular dystrophy and progeria, a premature aging syndrome.
Joffe and Solovei suspect that mutations in lamin A/C affect the expression of specific genes during the maturation and differentiation of cells, with deleterious results for their function and for tissue integrity. This notion could explain the highly diverse and complex symptoms seen in patients with mutations in the lamin A/C gene -- and it could open routes to the design of targeted therapies for laminopathies.
The new findings thus yield fundamentally new insights into how each of the many differentiated cell types in the body arises as the result of the precisely regulated expression of a specific complement of genes appropriate to each. "In the end, we have been brought from studies of night vision and an odd quirk of nature to the discovery of a fundamental regulatory mechanism: The nuclear envelope has a major say in development, and what kind of envelope our genetic material comes in makes a great deal of difference to our fate," Leonhardt concludes.
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Story Source:
The above story is reprinted from materials provided by Ludwig-Maximilians-Universitaet Muenchen (LMU).
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Irina Solovei, Audrey?S. Wang, Katharina Thanisch, Christine?S. Schmidt, Stefan Krebs, Monika Zwerger, Tatiana?V. Cohen, Didier Devys, Roland Foisner, Leo Peichl, Harald Herrmann, Helmut Blum, Dieter Engelkamp, Colin?L. Stewart, Heinrich Leonhardt, Boris Joffe. LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation. Cell, 2013; 152 (3): 584 DOI: 10.1016/j.cell.2013.01.009
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/38_3gzFCTbw/130201114110.htm
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South East Radio's Business Matters celebrates 12 months on air ...
South East Radio?s Business
Matters celebrates 12 months on air
This Saturday (February 2nd), marks the first anniversary of South East
Radio?s flagship business programme, Business Matters. The show, presented by
local entrepreneur Karl Fitzpatrick and sponsored by Wexford Insurances, has
become a focal point for local businesses.
Speaking about the success of the show, Liam Dwyer, General Manager of South East Radio
said ?We are delighted that South East Radio?s Business Matters has been so
well received by our listeners and we would like to thank Wexford Insurances,
who have renewed their sponsorship for a second year.?
Having featured interviews with all local and national funding agencies, South East
Radio?s Business Matters has provided listeners with comprehensive information
on a wide range of supports and grants available to businesses across County
Wexford. The show is also renowned for featuring interviews with high profile
companies and providing access to industry leaders that listeners want to know
more about.
Karl Fitzpatrick, presenter of South East Radio?s Business Matters, also shared his
thoughts on this milestone for the show, stating that ?Over the last 12 months,
I have thoroughly enjoyed sharing business success stories with our listeners and
providing practical solutions to the everyday challenges facing local
businesses. The quality of our guests has been instrumental in making the show
a success and I am committed to bringing more exclusive interviews to our
listeners in the year ahead.?
So tune into South East Radio?s Business Matters in association with Wexford Insurances
every Saturday morning from 10.30am to 11.30am.
Source: http://www.wexfordceb.ie/south-east-radio%E2%80%99s-business-matters-celebrates-12-months-on-air/
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Senthosa Island Where Boundless Excitement Awaits!
Known as Asia's Favourite Playground the Senthosa is home to an exciting list of themed attractions, exquisite hotels and spas and many more. It might be the only place in the region where you could walk among lush rainforests and within minutes step on a sun kissed golden beach. Spread on 500 hectares of land the beautiful island attracts thousands of visitors a day. Whether you are in Singapore on business or leisure visiting the Senthosa Island will be a rewarding experience.
Located 15 minutes away from the city centre the islands is on the Senthosa cove. With a growing residential community Senthosa is expected to have over 2000 homes by the end of 2014. Along with restaurants that offer romantic dining experiences and specialty shops that could awe even the worst shopaholics, Senthosa has something to offer to everyone.
Golf clubs with widely acclaimed gold courses, rides and thrills of all sorts, and cable rides are some of the most looked forward to excursions on the island. The adventure park is easily accessible via dedicated transport provided at the premises and into the premises. Many adventure seekers from around the world visit Singapore with the sole purpose of experiencing the park.
There are several sections of the park, the resorts world, Imbhia Lookout, the gorgeous beach along with its latest addition the Universal studios are some of the most visited attractions of the island. Although there are many accommodation options within the island, if staying amidst all the hustle and bustle is not your idea of ideal lodging there are many luxury hotels Singapore that will add to your experience of this beautiful country. The St. Regis Singapore is a hotel known for its world class hospitality and the legendary St. Regis Butler Service. 5 star hotels Singapore, the likes of the St Regis will pamper your senses from the minute you walk in through its doors and continue to dazzle you long after you leave the premises with memories of Singapore truly worth cherishing. Its 299 richly decorated rooms, provide unparalleled luxuries made up of authentic and international cuisine, heavenly spa treatments and world class service standards.
About the Author:
Thanuja Silva is a travel writer who writes under the pen name Auburn Silver. She has a passion for fashion and a deep interest in admiring new and exotic attractions around the world.
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Source: http://www.articlesnatch.com/Article/Senthosa-Island-----Where-Boundless-Excitement-Awaits-/4411095
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Best Buy Closing 15 Big Box Locations In Canada, To Be Replaced By Smartphone And Tablet-Focused Micro Stores
Best Buy Canada announced today that it will be closing 15 locations across the country, including seven Best Buy-branded locations, and eight stores bearing the Future Shop moniker (a Canadian electronics reseller Best Buy acquired in 2001). The store closures will result in 900 layoffs, but those employees will have first dibs on jobs at smaller outlets focused on mobile device sales the retailer plans to open in place of the closing stores.Source: http://feedproxy.google.com/~r/Techcrunch/~3/6pmSScwU-cs/
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Movies That Feature Women's Fashion And Style - Shopping and ...
The womens style tips you know may be confusing. ?While one individual reveals it?s much better to overdress, another tells you that less is better. ?A reliable root of fashion is the silver screen. ?Writers add extra effort to know which decade fashion soared the most and also which fashion designers are worth mentioning. ?I take many of my fashion wisdom from television shows just like ?Ugly Betty.? ?For people who can?t sit through twenty-four episodes which run for 40 minutes each, any of the five films mentioned here can give you a few useful fashion tips you ought to take seriously.
The 1st in the list is definitely an obvious choice from the title, ?The Devil Wears Prada.? ?One blog for women labeled it as a scary flick and the information was exactly right. ?Meryl Streep?s role could make any person either familiar with or unaware of fashion basics to shake in fear. ?However, this shock aspect gradually disappeared once the clothes and shoes were given screen time. ?You discover from this film that Jimmy Choos symbolizes an eternal love and your very first pair will mean trading your soul to well, the demon.
If you don?t like romantic comedies, opt for lowbrow settings that are also about fashion and style like ?Zoolander.? ?This movie makes fun at individuals in the industry, which is great for somebody who has taken fashion too profoundly. ?From this movie, you realize how beaming can cap off a style even when you can?t turn left.
If you like to drool over some shoes and handbags on-screen yet cannot afford to pull your feet to the shopping mall for worry of a window shopping spree becoming an actual indulgence, find comfort and a friend in the film ?Confessions of a Shopaholic.? ?I have not read the book yet the media hype alone overwhelmed and reached my fashion radar. ?What I learned from this movie is that a dazzling, new bag can comfort you better than a guy could. ?When you get hold of fashion but likewise learn the way to roll with it, you can make it work to your advantage.
Assortment in style and fashion is important, that is why I?ll add one more romantic comedy on the list. ?The 2001 chick flick ?Legally Blonde? has a hint of romantic relationships yet for me it boasts mostly of comedy and fashion. ?With this film, I found out that the concepts of proper hair care are simple and precise. ?Also, physical exercise not just creates great figure for almost any outfit but also brings down criminal rate.
The very last source of onscreen tips is from the film ?In Her Shoes,? which is actually a film adaptation of a blog about shoes but with extra drama and less plot. ?The wisdom of this film is easy to spot if you are the sentimental kind. ?It seems that shoes, or any other accessory, won?t fail to give life meaning without making you add any significant body weight.
Source: http://shopping-product-reviews.com/movies-that-feature-womens-fashion-and-style/
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